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Articles

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  1. The mucin-degrading bacterium Akkermansia muciniphila has attracted enormous interest for its beneficial effects on human health. However, growing evidence suggests that the Akkermansia genus is populated by seve...

    Authors: Cristian Molteni, Diego Forni, Rachele Cagliani and Manuela Sironi
    Citation: Biology Direct 2025 20:90
    Content type: Research Published on:

  2. Chloride intracellular channels (CLICs) are a family of six evolutionarily conserved proteins with diverse functions. Previously, we identified CLIC2, as the fifth-ranked master regulator associated with diffu...

    Authors: Viviana Longo, Pellegrino Mazzone, Giovanni Calice, Pietro Zoppoli, Giuseppina Di Paola, Giuseppe Cesta, Margherita Luongo, Claudia Sabato, Sabino Russi, Simona Laurino, Tiziana Notarangelo, Giuseppe Patitucci, Chiara Balzamo, Valeria Lucci, Elena Amendola, Giuseppina Amodio…
    Citation: Biology Direct 2025 20:89
    Content type: Research Published on:

  3. Ferroptosis and disulfidptosis are newly discovered forms of regulated cell death that play critical roles in cancer progression, metabolism, and immune evasion. However, their interplay and combined influence...

    Authors: Yifei Zhu, Huixia Huang, Jiayu Chen, Keji Chen, Yanxi Yao, Yaxian Wang, Yuxue Li, Zhibing Qiu, Dawei Li and Ping Wei
    Citation: Biology Direct 2025 20:88
    Content type: Research Published on:

  4. Despite significant advancements in therapeutic approaches for lung cancer, the prognosis of lung squamous cell carcinoma (LUSC) remains suboptimal, underscoring the critical need to identify novel molecular t...

    Authors: Jie Yang, Zhongfei Jia, Juan Li, Chao Jiang, Xin Zhao, Yuxiang Wang, Xiaoguo Ma and Xinjian Xu
    Citation: Biology Direct 2025 20:87
    Content type: Research Published on:

  6. Iron overload and ferroptosis are associated with intestinal ischemia and reperfusion (II/R)-induced acute lung injury (ALI). However, the mechanisms underlying the regulation of iron homeostasis remain unclea...

    Authors: Yunfan Gu, Hui Dong, Yanjun Wang, Beibei Hu, Hong Jiang and Rong Hu
    Citation: Biology Direct 2025 20:85
    Content type: Research Published on:

  7. Doxorubicin (DOX) is a potent chemotherapeutic widely used against various cancers, but its clinical application is limited by DOX-induced cardiotoxicity (DIC). This study explored the cardioprotective potenti...

    Authors: Wan-Tseng Hsu, Shinji Kobuchi, Tung-Chun Russell Chien, I-Chun Chen, Shohei Hamada, Masayuki Tsujimoto, I-Lin Tsai, Yun-Sheng Wong, Kuan-Hsuan Tung and Ying-Zhen He
    Citation: Biology Direct 2025 20:84
    Content type: Research Published on:

  8. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive pulmonary disease characterized by alveolar structural destruction and fibrosis. In recent years, efferocytosis has been recognized as playing a cru...

    Authors: Qian Jin, Yi Kang, Wenwen Jin, Ying Liu, Qian Chen, Jian Liu, Yali Guo and Yuguang Wang
    Citation: Biology Direct 2025 20:83
    Content type: Research Published on:

  9. Renal cell carcinoma (RCC), the most common solid tumor of the kidney, accounts for approximately 3% of all malignancies and has a higher incidence in Western countries. The current frontline treatment for met...

    Authors: Simone Patergnani, Pietro Zampieri, Nicoletta Bianchi, Carmelo Ippolito, Roberta Gafà, Giovanni Lanza, Mariusz R. Wieckowski, Paolo Pinton and Gianluca Aguiari
    Citation: Biology Direct 2025 20:82
    Content type: Research Published on:

  11. Cancer-associated fibroblasts (CAFs) have been reported to play a significant role in the development and metastasis of various tumors; however, research on their role in promoting prostate cancer (PCa) metast...

    Authors: Xiaodong Song, Tiewen Li, Wenhao Zhou, Chengling Feng, Zeng Zhou, Yuanming Chen, Deng Li, Lei Chen, Jing Zhao, Yu Zhang and Bangmin Han
    Citation: Biology Direct 2025 20:80
    Content type: Research Published on:

  12. Oxidative stress plays a crucial role in the development of diabetic foot ulcers (DFU). However, its underlying mechanisms are not fully understood. The purpose of this study was to use bioinformatics and prel...

    Authors: Jialiang Lin, Linjuan Huang, Weiming Li, Haijun Xiao and Mingmang Pan
    Citation: Biology Direct 2025 20:79
    Content type: Research Published on:

  13. Non-small-cell lung cancer (NSCLC) exhibits variable outcomes and remains a leading cause of cancer-related mortality, despite advances in immunotherapy. This study aimed to develop a prognostic model using re...

    Authors: F. V. Moiseenko, M. A. Krasavina, I. R. Agranov, E. V. Artemieva, A. P. Oganesian, A. S. Gabina, M. L. Makarkina, E. O. Elsakova, V. A. Henshtein, N. M. Volkov, V. V. Egorenkov, V. M. Moiseenko, M. Yu. Fedyanin, G. S. Kopeina, B. Zhivotovsky and A. V. Zamaraev
    Citation: Biology Direct 2025 20:78
    Content type: Research Published on:

  14. The prognosis for patients with head and neck cancer (HNC) is usually poor, highlighting the need for new therapeutic strategies. To this end, this study aims to evaluate the antitumor efficacy of a combined t...

    Authors: Valeria Lucarini, Valentina Angiolini, Daniela Nardozi, Monica Benvenuto, Chiara Focaccetti, Patrizia Mancini, Elena Splendiani, Tanja Milena Autilio, Claudio Cortese, Riccardo Bei, Gianluca Nicolai, Camilla Palumbo, Elisabetta Ferretti, Loredana Cifaldi, Roberto Bei and Laura Masuelli
    Citation: Biology Direct 2025 20:77
    Content type: Research Published on:

  16. Ovarian cancer is a complicated and heterogeneous disease. In this study, we investigated the functional significance of the gene TIMM8B, which is differentially expressed in ovarian cancer to better understan...

    Authors: Yue Jia, Jiaqian Liao, Xiangqun Yang, Hongyan Hu, Wentao Zhao, Liufang Zhao, Conghui Ai, Yuanbo Xue, Shufen Tan and Yi Zhang
    Citation: Biology Direct 2025 20:75
    Content type: Research Published on:

  17. Lung adenocarcinoma (LUAD) is one of the common malignant tumors worldwide, and the 5-year survival rate remains unsatisfactory. Reliable prognostic biomarkers are needed to provide references for personalized...

    Authors: Yuqing Dong, Ying Zhang, Haoran Liu, Xintong Jiang, Shuyang Xie and Pingyu Wang
    Citation: Biology Direct 2025 20:74
    Content type: Research Published on:

  18. In sepsis, immunosuppression is commonly observed as lipopolysaccharide (LPS) tolerance in macrophages. Leukocyte immunoglobulin-like receptor B2 (LILRB2) is an inhibitory receptor on immune cells that may pla...

    Authors: Ruojing Bai and Jun Guo
    Citation: Biology Direct 2025 20:73
    Content type: Research Published on:

  19. Pathological complete response (pCR) to neoadjuvant systemic therapy (NAST) is an established prognostic marker in breast cancer (BC). Multimodal deep learning (DL), integrating diverse data sources (radiology...

    Authors: Eriseld Krasniqi, Lorena Filomeno, Teresa Arcuri, Gianluigi Ferretti, Simona Gasparro, Alberto Fulvi, Arianna Roselli, Loretta D’Onofrio, Laura Pizzuti, Maddalena Barba, Marcello Maugeri-Saccà, Claudio Botti, Franco Graziano, Ilaria Puccica, Sonia Cappelli, Fabio Pelle…
    Citation: Biology Direct 2025 20:72
    Content type: Review Published on:

  20. Anti-Müllerian hormone (AMH) levels are frequently elevated in women with polycystic ovary syndrome (PCOS) and serve as a valuable diagnostic biomarker. However, the molecular mechanisms driving AMH overexpres...

    Authors: Yunmei Ke, Jinyan Zheng, Jinman Zhang, Dan Tang, Qin Yang, Han Zhao, Caifen Zhu and Yan Zhang
    Citation: Biology Direct 2025 20:71
    Content type: Research Published on:

  21. Breast cancer is subdivided into four distinct subtypes based on the status of hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) as HER2−/HR+, HER2+/HR+, HER2+/HR− and HER2−/HR−. Among th...

    Authors: Aswathy Sivasailam, Kiran S. Kumar, Aparna Geetha Jayaprasad, Shine Varghese Jancy, Ashwathi Harikumar, P. S. Unnikrishnan, K. C. Sivakumar, P. J. Jain Tiffee, Aman Munirpasha Halikar, S. S. Nithin, Prakash R. Pillai, Shivanshu Kumar Tiwari, Vishnu S. Sanjeev, A. V. Surabhi and T. R. Santhoshkumar
    Citation: Biology Direct 2025 20:70
    Content type: Research Published on:

  22. Autophagy is the primary catabolic process responsible for degrading intracellular components and potentially harmful cytosolic entities by delivering them to lysosomes. Notably, this mechanism is crucial for ...

    Authors: Rita Casetti, Fabiola Ciccosanti, Harpreet Kaur Lamsira, Carmela Pinnetti, Valentina Mazzotta, Serena Ciolfi, Alessandra Sacchi, Alessandra Amendola, Giuseppe Ippolito, Mauro Piacentini and Roberta Nardacci
    Citation: Biology Direct 2025 20:69
    Content type: Research Published on:

  23. As members of the nuclear receptor (NR) family of transcription factors, peroxisome proliferator-activated receptors (PPARs) regulate essential cellular processes, including lipid metabolism, glucose uptake, c...

    Authors: Pritha Saha, Palaniyandi Ravanan and Priti Talwar
    Citation: Biology Direct 2025 20:68
    Content type: Research Published on:

  24. Beta-2 microglobulin (β2m) is a small protein that forms the invariant subunit of the Major Histocompatibility Complex I. Monomeric β2m is stable under physiological conditions, however high local concentrations ...

    Authors: Cristina Visentin, Giulia Rizzi, Wen Yin, Mathilde Hotot, Dipambita Roy, Torbjörn Gräslund, Riccardo Capelli and Stefano Ricagno
    Citation: Biology Direct 2025 20:67
    Content type: Research Published on:

    The Correction to this article has been published in Biology Direct 2025 20:86

  25. Single-cell RNA sequencing (scRNA-Seq) technology reveals biological processes and molecular-level genomic information among individual cells. Numerous computational methods, including methods based on graph n...

    Authors: Shuo Wang, Yuanning Liu, Hao Zhang and Zhen Liu
    Citation: Biology Direct 2025 20:66
    Content type: Research Published on:

  26. Sepsis is a life-threatening condition with limited therapeutic options, characterized as excessive systemic inflammation and multiple organ failure. Macrophages play critical roles in sepsis pathogenesis. Alt...

    Authors: Yanjun Zheng, Jingrong Lin, Guoqing Wan, Xuefeng Gu and Jian Ma
    Citation: Biology Direct 2025 20:65
    Content type: Research Published on:

  27. Hepatocellular carcinoma (HCC) is among the deadliest cancers globally. Yes-Associated Protein (YAP), a Hippo pathway effector, crucially regulates cell proliferation and apoptosis. Recent research has implica...

    Authors: Xiaoyong Wei, Long Zou, Yanqing Huang, Chuan Qiu, Guang Cheng, Ye Chen and Jun Rao
    Citation: Biology Direct 2025 20:64
    Content type: Research Published on:

  28. Adaptor proteins play a crucial role in signal transduction by facilitating the assembly of protein complexes at specific subcellular domains. These multifunctional molecules contain multiple binding modules t...

    Authors: Mariana Di Felice, Lucrezia Romana Rolfi, Julian Toso, Valeria Pennacchietti, Eduarda S. Ventura, Angelo Toto, Antonella Tramutola and Stefano Gianni
    Citation: Biology Direct 2025 20:63
    Content type: Research Published on:

  30. Glioma is a malignant tumor associated with poorer prognosis. This study aims to elucidate the mechanism of LINC01018/miR-182-5p/Rab27B axis in PD-L1-mediated CD8+ T cell suppression in the progression of gliomas...

    Authors: Su Hu, Guoshuo Chen, Aiping Luo, Hailin Zhao, Dan Li, Biao Peng, Jike Du and Dongdong Luo
    Citation: Biology Direct 2025 20:61
    Content type: Research Published on:

  31. Protein arginine methyltransferases (Prmts) are essential regulators of various biological processes and have been implicated in the pathogenesis of numerous diseases. However, their role in osteomyelitis rema...

    Authors: Xun Chen, Ning Duan, Wentao Zhang, Tao Song and Fei Cong
    Citation: Biology Direct 2025 20:60
    Content type: Research Published on:

  32. Ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme with essential functions in protein trafficking and stability. It is a multidomain protein, with an N-terminal MIT (microtubule interacting and...

    Authors: Aimiliani Konstantinou, Julia K. Varga, Alicia Córdova-Pérez, Leandro Simonetti, Lidia Gomez-Lucas, Ora Schueler-Furman, Norman E. Davey, Yogesh Kulathu and Ylva Ivarsson
    Citation: Biology Direct 2025 20:59
    Content type: Research Published on:

  33. M2 macrophages play a crucial role in the initiation and progression of various tumors, including diffuse large B-cell lymphoma (DLBCL). However, the characterization of M2 macrophage-related genes in DLBCL re...

    Authors: Jiayi Zhang, Zhixiang Jia, Jiahui Zhang, Xiaohui Mu and Limei Ai
    Citation: Biology Direct 2025 20:58
    Content type: Research Published on:

  35. Mitotic catastrophe is well-known as a major pathway of endogenous tumor death, but the prognostic significance of its heterogeneity regarding bladder cancer (BLCA) remains unclear.

    Authors: Haojie Dai, Zijie Yu, You Zhao, Ke Jiang, Zhenyu Hang, Xin Huang, Hongxiang Ma, Li Wang, Zihao Li, Ming Wu, Jun Fan, Weiping Luo, Chao Qin, Weiwen Zhou and Jun Nie
    Citation: Biology Direct 2025 20:56
    Content type: Research Published on:

  36. Celiac disease (CD) is an autoimmune disorder that primarily affects the gut of genetically predisposed individuals and is triggered by gliadin peptides (PT) produced by the digestion of gluten. Although inapp...

    Authors: Romina Monzani, Mara Gagliardi, Valentina Saverio, Nausicaa Clemente, Alice Monzani, Ivana Rabbone, Francesca Nigrelli, Samuele Pellizzaro, Emanuele Ferrario, Silvia Saettone, Nico Pagano, Luigina De Leo, Dmitry Lim, Daniele Sblattero and Marco Corazzari
    Citation: Biology Direct 2025 20:55
    Content type: Research Published on:

  37. Hepatocellular carcinoma (HCC) is a common and challenging malignancy of the digestive tract. Unfortunately, patients with advanced HCC frequently experience limited long-term benefits from current treatments,...

    Authors: Shuiling Jin, Qi Zhao, Xiao Sun, Jinsong Su, Peiwen Wang, Peixian Li, Jing Guo, Yibing Zhang, Hong Zong and Xiaoli Gan
    Citation: Biology Direct 2025 20:54
    Content type: Research Published on:

  38. Aquaporin-5 (AQP5) is a crucial membrane protein involved in water transport across cellular membranes, particularly within exocrine glands such as salivary glands. Dysregulation of AQP5, including its misloca...

    Authors: Claudia D’Agostino, Egor Zindy, Louise Conrard, Amel Takkal, Françoise Gregoire, Nargis Bolaky, Susanna Törnroth-Horsefield, Jason Perret and Christine Delporte
    Citation: Biology Direct 2025 20:53
    Content type: Research Published on:

  39. Colorectal cancer (CRC) frequently metastasizes to the liver, worsening patient outcomes. The formation of a pre-metastatic niche (PMN) is essential for this process, but how the primary colon tumor orchestrat...

    Authors: ShuJie Li, Xue Fu, Deng Ning, QiuMeng Liu, JunFang Zhao, Qi Cheng, XiaoPing Chen and Li Jiang
    Citation: Biology Direct 2025 20:52
    Content type: Research Published on:

  40. Mutations in the tumour suppressor protein p53 are present in 70% of human pancreatic ductal adenocarcinomas (PDAC), subsequently to highly common activation mutation of the oncogene KRAS. These p53 mutations ...

    Authors: Kian Cotton, Charley Comer, Sabrina Caporali, Alessio Butera, Stephanie Gurres, Francesco Capradossi, Angelo D’Alessandro, Ivano Amelio and Maria Victoria Niklison-Chirou
    Citation: Biology Direct 2025 20:51
    Content type: Research Published on:

  41. The “psychedelic renaissance” is sparking growing interest in clinical research, along with a rise in clinical trials. Substances such as 3,4-methylenedioxymethamphetamine (MDMA), psilocybin and N,N-dimethyltrypt...

    Authors: Matteo Ardini, Francesco Angelucci, Francesca Rea, Luca Paluzzi, Federica Gabriele, Marta Palerma, Luana Di Leandro, Rodolfo Ippoliti and Giuseppina Pitari
    Citation: Biology Direct 2025 20:50
    Content type: Research Published on:

  42. Immunotherapy targeting the programmed death-ligand 1 (PD-L1) pathway is a standard treatment for advanced hepatocellular carcinoma (HCC). The Wnt signaling pathway, often upregulated in HCC, contributes to an...

    Authors: Yu-Yun Shao, Han-Yu Wang, Hung-Wei Hsu, Rita Robin Wo, Ann-Lii Cheng and Chih-Hung Hsu
    Citation: Biology Direct 2025 20:49
    Content type: Research Published on:

  43. Glioma is an aggressive brain tumor characterized by its high invasiveness, which complicates prognosis and contributes to patient resistance against various treatment options. The HOMER family, consisting of ...

    Authors: Furong Wang, Hui Zhou, Yu Tian, Xiaoling Wang, Youcai Huang, Yanyang Tu, Liwen Li and Haining Zhen
    Citation: Biology Direct 2025 20:48
    Content type: Research Published on:

  44. Patients diagnosed with gallbladder carcinoma (GBC) accompanied by hepatic metastasis exhibit unfavorable prognoses generally. Mitochondrial dysfunction promotes cellular transformation and cancer cell surviva...

    Authors: Ruopeng Liang, Xiaoxue Zhang, Shitao Wu, Jing Liu, Yunpeng Zhai, Chaojie Lin, Zhenya Wang, Yi Zhang, Hao Chen and Rongtao Zhu
    Citation: Biology Direct 2025 20:47
    Content type: Research Published on:

  45. Endothelial senescence (ES) contributes to aging-related disorders and triggers a senescence-associated secretory-pattern (SASP), releasing Extracellular Vesicles (EVs), potentially impacting atherosclerosis. ...

    Authors: Ignacio Hernandez, Laura Botana, Javier Diez-Mata, Laura Tesoro, Beatriz Jimenez-Guirado, Claudia Gonzalez-Cucharero, Nunzio Alcharani, Jose Luis Zamorano, Marta Saura and Carlos Zaragoza
    Citation: Biology Direct 2025 20:46
    Content type: Research Published on:

  46. Neutrophils play a key role in the tumor microenvironment (TME); however, their functions in glioblastoma (GBM) are overlooked and insufficiently studied. A detailed analysis of GBM-associated neutrophil (GBMA...

    Authors: Yufan Yang, Ziyuan Liu, Zhongliang Wang, Xiang Fu, Zhiyong Li, Jianlong Li, Zhongyuan Xu and Bohong Cen
    Citation: Biology Direct 2025 20:45
    Content type: Research Published on:

  47. Protein folding remains a fundamental challenge in molecular biology, particularly in understanding how polypeptide chains transition from denatured states to their functional conformations. Here we analyze th...

    Authors: Julian Toso, Valeria Pennacchietti, Mariana Di Felice, Eduarda S. Ventura, Angelo Toto and Stefano Gianni
    Citation: Biology Direct 2025 20:44
    Content type: Research Published on:

  48. Clear cell renal cell carcinoma (ccRCC) is the most common type of RCC. Even though the targeted drugs for the treatment of ccRCC have a certain therapeutic effect, due to the problem of drug resistance, the s...

    Authors: Bin Zheng, Kan Liu, Ji Feng, Qing Ouyang, Tongyu Jia, Yaohui Wang, Shuo Tian, Xinran Chen, Tianwei Cai, Lequan Wen, Xu Zhang, Xiubin Li and Xin Ma
    Citation: Biology Direct 2025 20:43
    Content type: Research Published on:

  49. Osteoporosis and kidney stones share several common pathophysiological risk factors, and their association is well-established. However, previous studies have primarily focused on environmental mediators, such...

    Authors: Di Luo, Linguo Xie, Jingdong Zhang and Chunyu Liu
    Citation: Biology Direct 2025 20:42
    Content type: Research Published on:

  50. Osteoarthritis (OA) is a degenerative joint disease marked by the breakdown of cartilage, where apoptosis plays a key role. Although apoptosis-related genes in OA have been studied, a detailed analysis of PANo...

    Authors: Daqian Zhou, Yingjin Luo, Fengjiang Li, Tao Liu, Yongliang Mei, Feilong Li, Xianghan Hou, Zhijiang Fu and Zongchao Liu
    Citation: Biology Direct 2025 20:41
    Content type: Research Published on:
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Biology Direct

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